منابع مشابه
DNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملSurgical repair of distal femoral fracture in a wild gray wolf (Canis lupus)
A 3-year-old wild gray wolf was referred to the Department of Veterinary Clinical Sciences of ShirazUniversity with a history of car accident. The radiographic examination showed supracondylar distal femoralfracture in right leg. The wolf was pre-medicated by acepromazine followed by induction of anesthesia usinga combination of diazepam and ketamine. Anesthesia was maintained by halothane. The...
متن کاملDNA repair in skin of lupus erythematosus following in vivo exposure to ultraviolet radiation.
The in vivo repair of pyrimidine dimers induced in the DNA of skin of 9 patients diagnosed as systemic or discoid lupus erythematosus (LE) was measured. A small area of the buttock was exposed to radiation emitted from a Burdick UV-800 sunlamp. The number of pyrimidine dimers was measured by incubating the epidermal skin DNA with UV-specific endonuclease and sedimenting the DNA through alkaline...
متن کاملDefective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
BACKGROUND Excessive autoantibody production characterizing systemic lupus erythematosus (SLE) occurs irrespective of the disease's clinical status and is linked to increased lymphocyte apoptosis. Herein, we tested the hypothesis that defective DNA damage repair contributes to increased apoptosis in SLE. METHODS We evaluated nucleotide excision repair at the N-ras locus, DNA double-strand bre...
متن کاملUnderexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus
INTRODUCTION Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by various systemic symptoms and multiple organ damage. We clarify biological and functional abnormalities in SLE by comparing the gene expression profiles of SLE patients with those of healthy individuals. METHODS Gene expression profiles from the peripheral blood of 21 SLE patients and 45 heal...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2014
ISSN: 1478-6354
DOI: 10.1186/ar4623